Arrhythmias associated with SSRI use in children and young adults

Czaja AS, Anderson HD, Ghosh D, Davidson J, Campbell JD, Valuck RJ. Increased Odds of Ventricular Arrhythmias Associated with Selective Serotonin Reuptake Inhibitor Use among the Pediatric and Young Adult Population: A Case-Control Study. J Pediatr 2020;226:173-8. Among children young adults, what is ventricular arrhythmia risk associated selective serotonin reuptake inhibitor (SSRI) use? Case–control study using IQVIA PharMetrics Health Plan Claims Database from 2007 to 2018. 75 US-based managed care plans. Cases: at least one event between ages 2 24 years. Controls: 10-times cases matched no events. SSRI or none. arrhythmia. Adjusting for mental health chronic conditions, use was arrhythmia, OR 5.1 (95% CI, 1.2 - 21.4). Subgroup analysis pediatric (2 17 years) versus adult (18 – did not demonstrate a difference. use.